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CV Arne Reimers

Career
2019 – present: Co-founder, co-owner Ljung & Reimers LLC, Malmö, Sweden
2018 – present: Senior consultant physician, Dept. of Clinical Chemistry and Pharmacology, Scania Region, Sweden
2018 – present: Lecturer, Lund University, Lund, Sweden 
2014 - 2018:    Associate professor, Inst. of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
2012 – 2013:   Head, Dept. of Clinical Pharmacology, St. Olavs University Hospital, Trondheim, Norway
2009 – 2018:   Post-doc researcher, Inst. of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
2006 – 2018:   Senior consultant physician, Dept. of Clinical Pharmacology, St. Olavs University Hospital, Trondheim, Norway
2006 – 2012:    Head of Medical Section, Dept. of Clinical Pharmacology, St. Olavs University Hospital, Trondheim, Norway
2004 - 2008:    Lecturer, Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
2002 – 2006:   Resident physician, Dept. of Clinical Pharmacology, St. Olavs University Hospital, Trondheim, Norway
1999 – 2002:   Head of International Marketing, Desitin Arzneimittel GmbH, Hamburg, Germany
1998 - 1999:    Deputy Head of Medical Marketing, Desitin Arzneimittel GmbH, Hamburg, Germany
1995 – 1997:    Deputy Head of Medical Department, Desitin Arzneimittel GmbH, Hamburg, Germany
1994 – 1995:    Medical Advisor, Desitin Arzneimittel GmbH, Hamburg, Germany
1993 – 1994:    Research fellow (post-doc), Dept. of Neuropharmacology, University of Göttingen, Germany
1991 – 1992:    Research fellow (post-doc), Dept. of Physiology, University of Kiel, Germany
 
Education
2011:      Dr. philos. (equiv. to PhD) Norwegian University of Science and Technology, Trondheim, Norway
2006:      Specialist in clinical pharmacology, St. Olavs University Hospital, Trondheim, Norway
1992:      Dr. med. (equiv. to PhD) University of Kiel, Germany
 
Experience & Skills
  • Experimental & clinical research: various in vivo-(animal) and in vitro-experimental methods, prospective clinical studies, database studies
  • Initiation and execution of interdisciplinary national and international collaborative projects
  • Planning and organizing clinical studies
  • Pharmacovigilance and drug safety
  • Strategic & operative marketing planning in the pharmaceutical industry
  • Scientific writing
  • Lecturing/teaching of medical students, medical doctors, psychologists, nurses and lab personell
  • Supervisor/advisor for medical students, master students, and PhD students
  • Strong analytical and presentation skills
  • Broad IT-knowledge (Windows, Linux, MS-Office, SPSS, image manipulation, etc.)
  • Languages: German, Norwegian, English, Swedish
 
Current Memberships and Appointments
  • Swedish Medical Association
  • Swedish Society of Physicians
  • Swedish Association for Basal and Clinical Pharmacology
  • Swedish Epilepsy Society (Swedish chapter of the ILAE)
  • Swedish Pain Society
  • Genomic Medicine Sweden (GMS)
  • International Society for the Study of Fatty Acids and Lipids (ISSFAL)
  • Fellow of the Royal Society of Medicine
  • Peer reviewer for scientific journals, such as Journal of Pediatric Neurology; Journal of Medical Toxicology; Journal of Pharmacoepidemiology and Drug Safety; Journal of Clinical Neuropharmacology; Journal of Clinical Pharmacy and Therapeutics; CNS Drugs; CNS Spectrums; British Journal of Medicine and Medical Research; Gender Medicine; Expert Opinion on Drug Metabolism and Toxicology; International Journal of Environmental Research and Public Health; European Journal of Drug Metabolism and Pharmacokinetics; Pharmacological Research; Epilepsy & Behavior; Drug Design, Development and Therapy; Expert Opinion on Neurology; Acta Neurologica Scandinavica; Epilepsia; Seizure - European Journal of Epilepsy;  European Journal of Clinical Pharmacology; Expert Review of Drug Discovery; Epilepsy Research and Treatment; European Journal of Neurology; British Journal of Clinical Pharmacology; Bipolar Disorders; Epilepsy Research; Basic & Clinical Pharmacology & Toxicology; Therapeutic Advances in Drug Safety; Journal of Clinical Psychopharmacology; Neuroscience letters; Journal of Clinical Psychiatry; Expert Review of Neurotherapeutics; Expert Review of Clinical Pharmacology; Drugs - Real World Outcomes; Case Reports in Pediatrics; Neurology and Therapy (Nature); Neuropsychiatric Disease and Treatment, etc.
 
Publications
A.      Selected abstracts, posters, and invited lectures
1.          Bohuslavizki KH, Hänsel W, Kneip A, Koppenhöfer E, Reimers A. Potassium chan­nel blockers from Ruta – a new approach for the treatment of multiple scle­rosis. Poster, Baltic Meeting on Pharmacology, Vilnius (1992)
2.          Reimers A, Brodtkorb E, Helde G: Ethinylestradiol, but not gestagens, reduces lamotrigine serum concentrations. Poster, 58th Annual Meeting of the American Epilepsy Society, New Orleans. Epilepsia 2004;45 (Suppl 7):143
3.          Reimers A, Brodtkorb E, Helde G, Spigset O: Lamotrigine serum concentrations throughout the menstrual cycle. Poster, 26th International Epilepsy Congress, Paris. Epilepsia 2005;46 (Suppl 6):108
4.          Reimers A, Skogvoll E, Kutschera Sund J, Spigset O. Interactions between lamotrigine and psychoactive drugs: Evidence from a therapeutic drug monitoring service. Poster, 7th EACPT Congress, Poznan, Poland, 25.-29.6.2005
5.          Reimers A: The role of TDM in the treatment of epilepsy. Lecture, Seminar ”The refractory epilepsy patient”, Århus sygehus, Århus, Danmark, 24.1.2013
6.          Reimers A: Klinisk farmakologi av lamotrigin. Lecture, Psykofarmakologisk forum, St. Olavs Hospital, Trondheim, 6.6.2013
7.          Reimers A: Nyere antiepileptika og fertile kvinner. Lecture, Vårmøte, Norsk nevrologisk forening. Trondheim, 8.6.2013
8.          Reimers A. Bivirkninger. Lecture, Epilepsi i praktiken. Stockholm, 10.10.2013
9.          Reimers A. TDM av antiepileptika. Lecture, Epilepsi i praktiken. Stockholm, 10.10.2013
10.     Reimers A: Graviditet og farmakokinetikk. Lecture, Course on Drug treatmnet in pregnancy and lactation. Oslo, 15.11.2013
11.     Reimers A: Nye antiepileptika ved svangerskap og amming. Lecture. Course on Drug treatmnet in pregnancy and lactation. Oslo, 15.11.2013
12.     Reimers A: Farmakokinetikk og CNS-kinetikk. Nevrokjemi og klinisk nevrofarmakologi. Lecture, Trondheim, 20.-22.11.2013
13.     Johannessen Landmark C, Svendsen T, Reimers A, Brodtkorb E, Sætre E, Molden E, Johannessen SI. Clinical experience with therapeutic drug monitoring of eslicarbazepine acetate in Norway. Poster, 11th European Congress on Epilepsy. Stockholm, 29.6. - 3.7.2014
14.     Samsonsen C, Reimers A, Bråthen G, Helde G, Brodtkorb E. Non-adherence to AEDs causing acute hospitalizations in people with epilepsy: An observational, prospective study. Poster & Lecture, 11th European Congress on Epilepsy. Stockholm, 29.6. - 3.7.2014
15.     Svendsen T, Landmark CJ, Reimers A, Brodtkorb E, Sætre E, Lossius MI, Johannessen SI. High retention rate in patients with refractory epilepsy treated with eslicarbazepine acetate. Poster, Annual Meeting of the American Epilepsy Society. Seattle WA, 5.-9.12.2014
16.     Reimers A. Non-CYP drug metabolizing enzymes. Chinese Academy of Chinese Medical Sciences. Lecture, Beijing, May 11, 2016
17.     Reimers A. Genregulering og epigenetikk. Kurs i farmakogenetikk. Trondheim, 9.-11-2-2016
18.     Shirzadi M, Reimers A, Helde G, Sjursen W, Brodtkorb E. No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants *2(P24T) or *3(L48V). Poster, 12th European Congress on Epilepsy. Prague, 11-15.9.2016
19.     Landmark CJ, Svendsen T, Reimers A, Brodtkorb E, Baftiu A, Burns ML, Johannessen SI. The impact of pharmacokinetic interactions with eslicarbazepine acetate versus oxcarbazepine and carbamazepine in clinical practice. Poster, 12th European Congress on Epileptology, Prague, September 11-15, 2016
20.     Olsson P, Reimers A, Nilsson J, Hoff E, Reis M, Strandberg M, Lundgren A, Källén K. LEV-SWITCH - Impact of generic substitution on levetiracetam serum concentration. Poster, 71st Annual Meeting of the American Epilepsy Society. 1-5 Dec 2017, Washington, DC.
21.     Reimers A. Introduction to UGT pharmacogenetics. Lectures. Course on pharmacogenetics. Trondheim, Norway, 29-31 November 2018.
22.     Reimers A. Pharmacokinetics of antiepileptic drugs during status epilepticus. Lecture. Spring Meeting of the Swedish Society of Neurology. 2019-05-16.
23.     Reimers A. Pharmacology of cannabinoids. Lecture. Annual Meeting of the Swedish Pain Society, 2020-10-09.
 
B.       Original papers & Reviews
Citations: 1 513; h-index: 20 (as of 2022-07-29)
  1. Ljung H, Reimers A: Drugs and cognition. Book chapter. In: Nyman H, Bartfai A (eds.): Clinical Neuropsychology. Studentlitteratur. Lund, Sweden 2022. In press.
  2. Shirzadi M, Saunes M, Reimers A, Brodtkorb E. Rash during lamotrigine treatment is not always drug hypersensitivity a retrospective cohort study among children and adults. Seizure - European Journal of Epilepsy 2021, Volume 89, 12 - 18
  3. Olsson P, Pearson K, Reimers A, Källén K. Widespread skeptic attitudes among people with epilepsy towards generic antiseizure drugs – A Swedish survey study. Epilepsy Behav 2021;114(Pt A):107554. doi: 10.1016/j.yebeh.2020.107554
  4. Reimers A. Antiepileptic Drugs. Book chapter. In: Offermanns S., Rosenthal W. (eds.) Encyclopedia of Molecular Pharmacology. 2020, Springer, Cham. https://doi.org/10.1007/978-3-030-21573-6_150-1
  5. Svensson M, Reimers A, Reis M. Pharmacokinetics of antidepressants during pregnancy. Läkartidningen 2020; 117 (17-18)
  6. Olsson P, Reimers A, Källén K. Quality of life after switching to generic levetiracetam - A prospective comparative study. Epilepsy Behav 2019; 96:169-174
  7. Reimers A, Ljung H. The emerging role of omega-3 fatty acids as a therapeutic option in neuropsychiatric disorders. Ther Adv Psychopharmacol 2019; 9:1-18
  8. Reimers A. Lamotrigine, bipolar disorder, and the pill‐free week. Bipolar Disord 2019; 21(4);372-373
  9. Reimers A., Ljung H. An evaluation of zonisamide, including its long-term efficacy, for the treatment of focal epilepsy. Exp Opin Pharmacother 2019;20(8):909-915
  10. Reimers A, Brodtkorb E. Therapeutic drug monitoring of antiepileptic drugs. Clin Lab Int Dec 2018/Jan 2019
  11. Hansen CC, Ljung H, Brodtkorb E, Reimers A. Aggressive behavior induced by antiepileptic drugs. Behavioural Neurology 2018; Volume 2018, article ID 2064027
  12. Reimers A, Helde G, Becser Andersen N, Aurlien D, Surlien Navjord E, Haggag K, Christensen J, Lillestølen KM, Nakken KO, Brodtkorb E. Zonisamide serum concentrations during pregnancy. Epilepsy Res 2018;144:25-29
  13. Westin AA, Reimers A, Spigset O. Should pregnant women receive lower or higher medication doses? Tidsskr Nor Legeforen 2018;17 
  14. Christensen J, Reimers A. Management of pregnant women with epilepsy who use lamotrigine. Epilepsy Research 2018 Jan 25. doi: 10.1016/j.eplepsyres.2018.01.009. [Epub ahead of print]
  15. Reimers A, Andsnes Berg J, Larsen Burns M, Brodtkorb E, Johannessen SI, Johannessen Landmark C. Reference ranges for antiepileptic drugs revisited - a practical approach to establish national guidelines. Drug Des Devel Ther 2018; 12:271-280. DOI: 10.2147/DDDT.S154388
  16. Reimers A, Andsnes Berg J, Johannessen Landmark C. Harmonised reference ranges for antiepileptic drugs. Tidsskrift Nor Legeforen 26-06-2017; DOI: 10.4045/tidsskr.17.0392
  17. Reimers A, Olsson P, Nilsson J, Hoff E, Reis M, Strandberg M, Lundgren A, Källén K. Impact of generic substitution on levetiracetam serum concentration – a prospective study in an outpatient setting. Epilepsy Res 2017; 134:54-61
  18. Shirzadi M, Reimers A, Helde G, Sjursen W, Brodtkorb E. No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants *2(P24T) or *3(L48V) in Norwegian patients. Seizure 2017; 45:169-171
  19. Svendsen T, Brodtkorb E, Reimers A, Molden E, Sætre E, Johannessen SI, Johannessen Landmark C. Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate-A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome. Epilepsy Res 2017; 129:125-131
  20. Reimers A. Hormone replacement therapy with estrogens may reduce lamotrigine serum concentrations: a matched case-control study. Epilepsia 2016. DOI: 10.1111/epi.13597.
  21. Johannessen Landmark C, Svendsen T, Dinarevic J, Kufaas RF, Reimers A, Brodtkorb E, Baftiu A, Burns ML, Johannessen SI. The impact of pharmacokinetic interactions with eslicarbazepine acetate versus oxcarbazepine and carbamazepine in clinical practice. Ther Drug Monit. 2016;38(4):499-505
  22. Reimers A. Contraception for women with epilepsy: counseling, choices, and concerns. Open Access J Contraception 2016:7 69–76
  23. Brodtkorb E, Samsonsen C, Sund JK, Bråthen G, Helde G, Reimers A. Treatment non-adherence in pseudo-refractory epilepsy. Epilepsy Res 2016; 122:1-6
  24. Samsonsen C, Reimers A, Bråthen G, Helde G, Brodtkorb E. In response: Non-adherence to treatment causing acute hospitalizations in people with epilepsy: An observational, prospective study. Epilepsia 2015;56(2):320-1
  25. Reimers A, Brodtkorb E, Sabers A. Interactions between hormonal contraception and antiepileptic drugs - Clinical and mechanistic considerations. Seizure 2015; 28:66-70
  26. Reimers A, Sjursen W, Helde G, Brodtkorb E. Frequencies of UGT1A4 *2 (P24T) and *3 (L48V) and their effects on serum concentrations of lamotrigine. Eur J Drug Metabol Pharmacokin 2016;41(2):149-55
  27. Samsonsen C, Reimers A, Bråthen G, Helde G, Brodtkorb E. Non-adherence to treatment causing acute hospitalizations in people with epilepsy: An observational, prospective study. Epilepsia. 2014 Nov;55(11):e125-8
  28. Reimers A. New antiepileptic drugs and women. Seizure 2014;23(8):585-91.
  29. Samsonsen C, Bråthen G, Reimers A, Helde G, Brodtkorb E. Is dietary caffeine involved in seizure precipitation? Epilepsy Behav 2013;28(2):147-150
  30. Reimers A, Nakken KO, Lossius R, Brodtkorb E. Antiepileptika og førerkort – nye retningslinjer bør revideres. Tidsskrift Nor Legeforen 2012; 132:2040-2041
  31. Saga LC, Liland KH, Leistad R, Reimers A, Rukke EO. Relating fatty acid composition in human fingertip blood to age, gender, nationality and n-3 supplementation in the Scandinavian population. Int J Food Sci Nutr. 2012; 63(7):790-5
  32. Reimers A, Brodtkorb E. Second generation AEDs and pregnancy: a guide for clinicians. Expert Rev Neurother 2012;12(6):707-17.
  33. Esmurziev A, Reimers A, Andreassen A, Zahlsen K, Sundby E. Preparation, characterization and quantitative analysis of lamotrigine-N2-glucuronide. Molecules 2012, 17(1), 820-835
  34. Reimers A. Clinical pharmacology of lamotrigine. Doctoral thesis, The Medical Faculty, NTNU, Trondheim, 2011:159
  35. Dyrkorn R, Reimers A, Johannessen L, Spigset O. Påvisning av rusmidler i urin - dekker testene de aktuelle misbruksstoffene? Tidsskr Nor Legeforen 6, 2011; 131: 570–2
  36. Reimers A, Helde G, Bråthen G, Brodtkorb E. Lamotrigine and its N2-glucuronide during pregnancy: the significance of renal clearance and estradiol. Epilepsy Res 2011; 94:198-205
  37. Reimers A, Østby L, Stuen I, Sundby E. Expression of UDP-glucurono¬syl¬trans¬ferase (UGT) 1A4 in human placenta at term. Eur J Drug Metab Pharmacokinet 2011; 35(3-4):79-82
  38. Reimers A. Ett antibiotika? Flere antibiotiker? Antibiotikaer? Tidsskr Nor Legeforen 2010; 130:2150
  39. Hønnås A, Reimers A, Spigset O. Dosering av digitoksin i klinisk praksis. Tidsskrift for Den norske legeforening 2010 ;130(13/14):1334-1336
  40. Westin AA, Nakken KO, Johannessen SI, Reimers A, Lillestølen KM, Brodtkorb E. Serum concentration/dose ratio of topiramate during pregnancy. Epilepsia 2009; 50(3):480-485
  41. Reimers A. Trends and changes in the clinical use of lamotrigine. Pharmacoepidemiol Drug Saf 2009;18(2):132-9.
  42. Westin AA, Reimers A, Helde G, Nakken KO, Brodtkorb E. Serum concentration/dose ratio of levetiracetam before, during and after pregnancy. Seizure 2008;17(2):192-198
  43. Brodtkorb E, Reimers A. Seizure control and pharmacokinetics of antiepileptic drugs in pregnant women with epilepsy. Seizure 2008;17(2):160-165
  44. Helland A, Espnes KE, Reimers A, Aamo T, Zahlsen K, Rygnestad T, Spigset O. Legemiddel- og rusmiddelanalyser som øyeblikkelig hjelp. Tidsskr Nor Lægeforen 2008;128: 42-5
  45. Reimers A, Skogvoll E, Sund JK, Spigset O. Lamotrigine in children and adolescents: The impact of age on its serum concentrations and on the extent of drug interactions. Eur J Clin Pharmacol 2007;63(7):627-629
  46. Reimers A, Reinholt G. Acute lamotrigine overdose in an adolescent. Ther Drug Monitor 2007;29(5):669-670
  47. Reimers A, Langsetmo HK. Combined overdose of atomoxetine and methylphenidate in a cytochrome P450 2D6 poor metabolizer. J Clin Psychopharmacol 2007;27(1):110-111
  48. Reimers A, Brodtkorb E, Helde G, Spigset O. Lamotrigine serum concentrations throughout the menstrual cycle – a study of two subjects. J Clin Neuropharmacol 2006;29(3):160-2
  49. Castberg I, Reimers A, Sandvik P, Aamo TO, Spigset O. Adverse drug reactions of antidepressants and antipsychotics: Experience, knowledge and attitudes among Norwegian psychiatrists. Nord J Psychiatry. 2006;60(3):227-33.
  50. Reimers A, Helde G, Brodtkorb E. Ethinyl estradiol, not progestogens, reduces lamotrigine serum concentrations. Epilepsia 2005;46(9):1414-7
  51. Reimers A, Skogvoll E, Kutschera Sund J, Spigset O. Drug interactions between lamotrigine and psychoactive drugs: Evidence from a therapeutic drug monitoring service. J Clin Psychopharmacol 2005;25(4):342-348
  52. Reimers A. P-piller kan påvirke metabolismen av andre legemidler. Tidsskr Nor Lægeforen 2004; 124:1785-7
  53. Reimers A, Spigset O. Declaration of fructose and fructose-related adverse effects in commercial drug preparations in European countries. Drug Safety 2003;26(14):1057-1059
  54. Vetterlein F, Reimers A, Schmidt G. Changes in renal microcirculation induced by infusion of (Fe3+)- and (Fe2+)-myoglobin during hemorrhagic hypotension in the anesthetized rat: influence of L-NAME and 8-Br-cyclic GMP. Nephron 1996;73(2):243-50
  55. Koppenhöfer E, Ditzen G, Gerst F, Reimers A. Kaliumkanalblocker in der Neurologie. TW Neur Psychiatrie1995; 9:585-591
  56. Bohuslavizki KH, Hänsel W, Kneip A, Koppenhöfer E, Reimers A, Sanmann K. Reduction of MS-related scotomatas by a new class of potassium channel blockers from Ruta graveolens. Neuro-ophtalmology1993;13(4):191-198
  57. Bohuslavizki KH, Hänsel W, Kneip A, Koppenhöfer E, Reimers A, Sanmann K. Blocking of potassium channels in Ranvier nodes by 4,5,6,7-substituted benzofurans and its significance on demyelinating diseases. Gen Physiol Biophys 1993;12(3):293-301
  58. Bohuslavizki KH, Hänsel W, Kneip A, Koppenhöfer E, Reimers A. Potassium channel blockers from Ruta – a new therapeutic approach for the treatment of multiple sclerosis. Gen Physiol Biophys 1992;11(4):507-512
  59. Inselmann G, Kutzschbach A, Heidemann HT. Amphotericin B and sodium deoxycholate induced impairment of renal p-aminohippurate accumulation (PAH) and effect on lipid peroxidation in the rat kidney. Ren Fail 1992;14(1):17-21
  60. Reimers A. Der Einfluß von Amphotericin B auf die p-Aminohippursäureakkumulation in der Niere. Doctoral thesis. The Medical Faculty, Christian-Albrechts-Universitet, Kiel. (1992)
Ljung & Reimers AB | Org.nr. 559196-9224 | Bankgiro 256-8830 | F-skatt  | Postadress: Köpenhamnsvägen 67 B, 217 71 Malmö